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first_img[Photo via Instagram User @cbs517] At Sound Summit music festival yesterday in the San Francisco Bay Area, Wilco welcomed a slew of talented guests during their headlining set. At the beginning of the late-afternoon show’s encore, singer-guitarist Jeff Tweedy called guitarist Bill Frisell (who had performed earlier in the day) and his pedal steel-playing bandmate Greg Leisz to the stage to lend a hand on “Hesitating Beauty” and “Christ For President”.But the surprises didn’t stop there! Local native Bob Weir of The Grateful Dead joined the band onstage next, adding his guitar and voice to the mix as they ran through “California Stars” and, finally, The Beatles‘ “Tomorrow Never Knows”.You can watch fan-shot video of “Tomorrow Never Knows” below, thanks to Youtube user jared baird:last_img read more


first_imgRailroad Earth has announced plans for a two-night 2018 Thanksgiving Run. Dubbed Horn O’ Plenty, the run will see Railroad Earth will headline Stroudsburg, PA’s Sherman Theater on Friday, November 23rd with support from Ghost Light and on Saturday, November 24th, with support from the Amy Helm Band. Railroad Earth’s Thanksgiving runs in Stroudsburg, PA have become an annual tradition, with this year marking the band’s eighth year in a row the band bringing their tight-knit jam-grass outfit to Stroudsburg to give thanks. Stay tuned for more information on all of the events happening in downtown Stroudsburg, PA for the Horn O’ Plenty weekend.Railroad Earth has a busy fall coming up, with appearances at Feastival, Waterloo Music Festival, Ardmore Music Hall in Ardmore, PA, The Festy Experience, Hillberry Festival, Bridge Jam Festival, and their highly anticipated three headlining nights at Hangtown Music Festival in Placerville, CA. The band is also slated to perform at Strings & Sol in Mexico this December, and Bender Jamboree in Las Vegas, NV next April.Horn O’ Plenty early bird 2-day passes and single day tickets are available now for a limited time via Ticketfly.For a full list of Railroad Earth’s upcoming tour dates and ticket information head to the band’s website.last_img read more


first_imgTreatment that increases brain levels of an important regulatory enzyme may slow the loss of brain cells that characterizes Huntington’s disease (HD) and other neurodegenerative disorders.  In a report receiving advance online publication in Nature Medicine, a Massachusetts General Hospital (MGH)-based research team reports that increased expression of Sirt1, one of a family of enzymes called sirtuins, in the brain of a mouse model of HD protected against neurodegeneration. They also identified a potential mechanism for this protective effect.“Diseases such as Huntington’s, Parkinson’s, and Alzheimer’s disease have different causative factors, but they share common themes — such as aggregation of misfolded proteins — and a unifying end point, the degenerative loss of neurons,” says the study’s senior author Dimitri Krainc of the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) and Harvard Medical School, where he is an associate professor of neurology. “Pharmacological targeting of Sirt1 may provide an opportunity for therapeutic development in HD and, more generally, in the neurodegenerative disorders of aging.”HD is an inherited disorder caused by a mutation in the gene for a protein called huntingtin. Deposits of the abnormal protein accumulate within the brain, causing destruction of brain cells.  Symptoms of HD usually first appear in the middle years and worsen over the 10- to 30-year course of the disorder, leading to death from a variety of complications.  Sirt1 is an important regulator of the activity of proteins involved in many critical functions — including energy metabolism, inflammation, and stress tolerance — and recent studies have suggested it protects against the effects of several neurodegenerative diseases.In experiments with a mouse model of HD, the researchers first showed that knocking out Sirt1 expression in the brain accelerated the appearance of HD-like pathology — such as aggregates of mutant huntingtin and increased cell damage in key areas of the brain.  In contrast, a strain of HD mice in which Sirt1 was overexpressed lived longer, with significantly less neurodegeneration and huntingtin aggregation, than did HD mice in which Sirt1 expression was unaltered.  Cellular experiments showed that Sirt1 overexpression directly protects neurons from the toxic effect of mutant huntingtin.The MGH-MIND team also discovered a new target for Sirt1 activity in TORC1, a brain protein known to regulate several important neuronal genes, and found that the presence of mutant huntingtin interferes with the interaction between Sirt1 and TORC1, reducing expression of the regulated genes.  In the same issue of Nature Medicine, a research team based at Johns Hopkins School of Medicine reports similar neuroprotective effects for Sirt1.  Co-authored by members of Krainc’s team, the Hopkins study demonstrated that mutant huntingtin inhibits the activity of Sirt1, leading to deregulation of multiple Sirt1 targets, in two additional HD mouse models.“Development of therapeutic agents for neurodegenerative diseases requires an in-depth understanding of the mechanisms that link the underlying biology with the resulting neuronal dysfunction,” says Krainc. “Developing and testing Sirt1 activators that protect against disorders like HD will require accurate information on Sirt1 activity in the normal and diseased brain.  We hope our studies can contribute valuable data to that effort, which will require collaborations with NIH, with industry, and with foundations such as the Cure Huntington’s Disease Initiative, one of the supporters of this study.”Additional supporters of the investigation are the National Institutes of Health, the Hereditary Disease Foundation, and the Glenn Foundation for Medical Research.last_img read more


first_imgWith an announcement made last Wednesday, Jan. 22, President Obama launched a new White House Task Force for protecting students nationwide against sexual assault.Obama is giving the task force, comprised of U.S. Government administrative officials, 90 days to come up with sexual assault prevention and response suggestions for colleges. The group is also tasked with proposing ways to increase public awareness and possibly creating a reinforcement system of federal agencies for schools that do not confront this rising problem.Prompted by a report made by the White House Council on Women and Girls, the President’s announcement states that 1 in 5 women are sexually assaulted at college, with only12 percent of assaults reported. The report said issues of sexual assault on college campuses related to drug and alcohol use should be especially examined because these substances have been found to have incapacitated many victims of sexual assault.Obama said he sees a need for college to be a safe place that harbors individual growth and that “it’s not just these individuals and their families who suffer … our communities- our whole country — is held back.”Notre Dame has already made strides independent of the federal government’s efforts,  attempting to address this serious concern.Student body president Alex Coccia said Student Government’s “One is Too Many” campaign has been put in place to “bring the topic of sexual violence into mainstream consciousness and conversation and to develop an attitudinal shift that leads to a culture that understands sexual violence and actively works to prevent it.”Coccia spoke on this topic before the National Campus Leaders Council, where he said Notre Dame can stand as an example for other schools and the task force to turn to when looking for solutions.“The discussion nationally is crucial to our efforts on campus.  It shows that our efforts here at Notre Dame have the backing of the national conversation, and that no one is alone in their efforts to respond to and prevent sexual violence,” said Coccia.The University administration has taken similar steps, creating the Committee on Sexual Assault Prevention and working directly with student government to develop policies directed toward preventing sexual assault, student body vice president Nancy Joyce said.Joyce said she has worked on the sexual assault issue in the past and is in favor of this new initiative from the White House. Joyce said she believes the new task force will work in tandem with the system that Notre Dame has in place, bringing about increased awareness not just on campus but across the entire United States.“The timing of President Obama’s announcement both enhances and supports our ‘One Is Too Many’ campaign,” Joyce said.The approach Obama indicated is similar to that taken thus far by the University and Student Government, with some adjustments to the unique aspects of Notre Dame, Joyce said.“President Obama mentioned that he hopes a stronger sense of peer pressure on college campuses will help to prevent sexual assault,” she said. “To some degree, this is the approach we are taking here at Notre Dame, but I think Alex and I are more focused on the idea that Notre Dame’s sense of community is what will enable us to take better care of each other.”Coccia said he hopes the White House initiative will finally bring due attention to this increasing problem from the rest of the country. Coccia also said he is optimistic this announcement will stand as an important commitment by the White House to preventing sexual assault.“Our goals nationally and on campus are to break that silence and ensure that men take responsibility in these efforts,” Coccia said. “This is so important in the residential structure at Notre Dame, where leaders in male dorms have the unique opportunity to set the standard of behavior for all classes within the dorm.”As for the future of Notre Dame and the White House task force, Coccia said he believes promoting active bystander intervention, speaking out against trivializing sexual assault language and supporting the healing of survivors will be the main responsibilities of all those involved.Tags: Alex Coccia, Nancy Joyce, One is too many, President Obama, sexual assault, Student government, White House Council on Women and Girlslast_img read more


first_img Related Shows About the Artist: With a desire to celebrate the magic of live theater and those who create it, and with a deep reverence for such touchstones as the work of Al Hirschfeld and the wall at Sardi’s, Squigs is happy and grateful to be among those carrying on the traditions where theater and caricature meet. He was born and raised in Oregon, lived in Los Angeles for quite a long time and now calls New York City his home. There’s truly “something about this night!” Finding Neverland takes flight and opens officially at the Lunt-Fontanne Theatre on April 15. The new musical from Gary Barlow, Eliot Kennedy and James Graham stars Matthew Morrison, Kelsey Grammer and Broadway.com vlogger Laura Michelle Kelly. Tony winner Diane Paulus directs.In addition to Morrison as J.M. Barrie, Grammer as Charles Frohman (with a tease of Captain Hook) and Kelly as Sylvia Llewelyn Davies, the portrait features Carolee Carmello as Mrs. du Maurier and Teal Wicks as Mary Barrie, as well as Aidan Gemme, Sawyer Nunes, Christopher Paul Richards and Alex Dreier as the Llewelyn Davis boys: Peter, George, Jack and Michael.Broadway.com wishes the cast of Finding Neverland a magical opening night! We’ll be in the audience clapping and believing! View Commentscenter_img Finding Neverland Show Closed This production ended its run on Aug. 21, 2016last_img read more


first_imgA survey conducted by Opinion Dynamics for the New England Energy Alliance found New Englanders favor market-based approaches to limit greenhouse gas emissions and improve energy efficiency by a significant margin in comparison to government regulation and mandates. There also seems to be no inclination to roll back electricity industry restructuring as a very significant 78% of survey respondents at least somewhat favor consumer choice and competition for electricity.78% say they favor competition in the electricity industryHistorically, electricity was delivered by regulated electric utility companies that acted like monopolies. They were mandated by state regulators to build and operate generating plants, as well as deliver electricity to homes and businesses. The New England states, however, were among the first in the nation to restructure electricity markets beginning in the late 1990s. In short, most electric utilities were required to sell their generating plants and allow unregulated privately-owned generation companies to compete in a deregulated wholesale marketplace. The utilities, now known as “local distribution companies”, deliver electricity and remain state regulated.A key goal of restructuring was to provide consumers with “choice” — the option to purchase electricity from competitive suppliers. All the New England states, with the exception of Vermont, introduced competition into retail markets.Ten years after restructuring, 78% of New Englanders are at least somewhat in favor of the concept of having consumer choice in the purchase of electricity — with 45% strongly in favor. This support remains unchanged over the past year.The concept of consumer choice is favored fairly equally across political party lines, but especially among independent voters — 81% favor the concept of consumer choice in the purchase of electricity compared to about 77% of Democrats and Republicans. Importantly, there were no major geographical differences of opinion among voters — with at least 74% favoring competition in each state.As is the case with many major public policy initiatives like electricity industry restructuring, once they are in place for just a few years, they become accepted “tradition” — no matter how “radical” they may have seemed at the outset.A number of independent studies (as well as one by the New England Energy Alliance in 2006) have shown that electricity industry restructuring has helped to better protect the environment through increased generating efficiency, and provided consumers with substantial savings compared to pre-restructuring trends.Almost 50% believe the marketplace will provide needed infrastructure without government interventionShortly after New England restructured its electricity industry in 1999, significant progress was made in expanding the region’s electricity infrastructure. An unprecedented 10,000 Megawatts of new generation was added, increasing the region’s electricity supply by 30%. Soon thereafter, construction of new generation slowed because the marketplace lacked appropriate financial incentives to attract long-term investment.As a result, the Federal Energy Regulatory Commission (FERC) charged ISO New England (the region’s independent operator of the electricity grid) with developing a market-based approach to ensuring adequate investment in infrastructure. Prior to restructuring, state government agencies played a key role in mandating an adequate supply of electricity.ISO New England, with industry stakeholder participation, created a competitive market structure — called the Forward Capacity Market (FCM) — that provides economic incentives through an auction process to attract investment in new and existing resources in New England. The region’s first FCM auction was held in February, 2008.Almost half of the survey respondents (47%) believe the competitive marketplace will provide adequate financial incentives to spur investment in new generating plants and infrastructure projects. On the other hand, a little over a third (36%) believe ensuring an adequate electricity supply is too important to be left to market forces alone — and should be the responsibility of government agencies as well.Many also favor market-based approaches to electricity efficiency and emissions reductionNew Englanders were also asked which of the following three approaches would be the best option to decrease the amount of electricity we use:Mandated government programs paid by all consumersMarkets should be allowed to workGovernment standards for appliancesGovernment mandated programs were weakly supported by just 15% of the respondents. The other two choices were even at about 34%. Interestingly, when they are added together, these two choices (which could as a practical matter be easily implemented together) come close to the super majority that favors consumer choice and competition. This suggests that consumers favor government efficiency standards (which have been in place for decades) but want them implemented by the marketplace so that they have choice and competition.In terms of the environment, less that a third favor government mandates to limit greenhouse gas emissions from electricity generating plants through the imposition of taxes and increasingly tougher mandates that a generating plant would have to comply with or face shutdown. Instead, the majority of New Englanders support a market-based approach that uses profit as a motive for companies to invent, improve, or acquire a way to cost-effectively and flexibly reduce their emissions.About New England Energy Alliance, Inc.The New England Energy Alliance is a coalition of energy providers and trade organizations concerned about future energy supplies.The annual telephone survey was conducted by Opinion Dynamics for the New England Energy Alliance in January of 600 registered voters (consumers) proportionately distributed throughout New England. The margin of error is +/- 4%.last_img read more


first_imgSign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York By Chris VaccaroThe New York Islanders are Brooklyn’s team now. After 43 years of playing games at Nassau Veterans Memorial Coliseum, the franchise opened the season in its new digs 30 miles west at Barclays Center.The Islanders welcomed the defending Stanley Cup champion Chicago Blackhawks to their housewarming, and ultimately lost the first regular season NHL game on Atlantic Avenue, 3-2, in overtime Friday night before an announced sellout crowd of 15,795.Patrick Kane scored two goals for Chicago, including a power play tally in overtime to ice the game.It was fitting that Islanders captain John Tavares scored the team’s first goal at Barclays when he netted a rebound just in front of Chicago goalie Corey Crawford at 5:22 of the first period.“I thought about that when he scored, probably just like everybody else,” said Islanders coach Jack Capuano. “He’s your captain, your best player. First game here in Brooklyn and he bangs the first one in. It’s something that he’ll remember and it’ll go down in history.”There were some noticeable differences in the arena compared to the Coliseum, including a slow ice surface that appeared to aid in the first goal of the game. Chicago’s Artem Anisimov, who picked off a pass from Brock Nelson intended for Nick Leddy, skated down ice to beat Islanders’ goalie Thomas Greiss on a shorthanded goal with 13:28 left in the first.“It wasn’t great,” Tavares said of the ice, also noting that they’re still adjusting to the new confines.Multiple pucks took random caroms and odd bounces from the texture of the ice and fresh boards.“The boards are pretty hot here,” said Chicago’s Kane. “[Pucks] come off pretty fast. You could see a lot of missed plays tonight, where you missed shots on net and they come right back out to the slot. There are some chances to be had there.”The aesthetics and ambiance were also different from what the team and fans would normally expect at the Coliseum.“I thought the fans were into it,” said Islanders coach Capuano. “It was loud. Obviously a different atmosphere than the Coliseum, but the guys were looking forward to this game and dropping the puck here tonight.”There are noticeably fewer Islanders banners hanging in the rafters, though they did retain the banners that honor the team’s Stanley Cup championships and retired jersey numbers.All conference and division championships have been condensed to two banners, however, compared to the myriad of orange, white and blue historic pieces that used to hug the Coliseum rafters for decades.“There’s no secret it’s a new time for the franchise,” said Tavares. “It certainly is a little different and I think it’s just some getting used to. I think it’s new, but I don’t think you ever want to change what the Islanders are and what they represent, and what they’ve done, and certainly what we’re trying to do. I know our fans are passionate about that. I think the organization is that way, and the guys in here understand that as well.”Among the fans in attendance for the historic game was Dan Wittekind of Holbrook, a former season-ticket holder.“My Dad and I were season-ticket holders since 2000 but not anymore,” he told the Press. “I think we may try to go to about 10 games this season. It’s just too long for us to travel on the train.”Also on hand was Acting Nassau County District Attorney Madeline Singas, a Democrat who was looking to secure votes in next month’s Election Day race against Republican Hempstead Town Supervisor Kate Murray, who wants to replace Singas as DA.Many Isle’s fans blame Murray for the team moving to Brooklyn, pointing to the town board’s decision during her tenure that effectively killed outgoing owner Charles Wang’s Lighthouse Project. The sentiment was summed up in a sign several fans held that replaced the “K” with an “H” on one of Murray’s campaign signs so it read “Hate Murray.”An Islanders fan replaced the “K” with and “H” in Kate Murray’s campaign sign. (Photo by Joseph Nuzzo)last_img read more


first_img“Your wife or your mom, just give them a hug and thank them for their contribution, even if it’s toward your family,” Micha said. “Just little acts of kindness go a long way.” (WBNG) — As National Women’s History month kicks off around the country, here in the Southern Tier, the celebrations are about to begin. “Women are unseen and unnoticed, so it’s important to have that recognition, that pride and that honor to show what we have done,” Micha said. “There are still women today who are trying to break the glass ceiling.” On Monday March 2 at 1 p.m. at Binghamton City Hall, the Status of Women Council will hold a flag raising ceremony. As the month-long celebration goes on, Micha gave advice for how people at home can honor the women who have impacted their lives. The annual tradition will see the flag wave throughout the entire month of March in recognition of women’s achievements and legacies throughout Broome County and the nation. The council’s president Heather Micha told 12 News the month is important to help women get the recognition they deserve.last_img read more


first_imgPierre-Emerick Aubameyang & Ainsley Maitland-Niles speak out on their Arsenal futures Advertisement Follow Metro Sport across our social channels, on Facebook, Twitter and Instagram.For more stories like this, check our sport page. Pierre-Emerick Aubameyang scored the decisive penalty in Arsenal’s Community Shield win over Liverpool (Picture: Getty)Pierre-Emerick Aubameyang has hinted his future at Arsenal will become clearer within in a matter of days.The Gunners skipper underlined his importance to Mikel Arteta’s side with another decisive Wembley performance, hot on the heels of matchwinning displays against Manchester City and Chelsea in last season’s FA Cup triumph.Aubameyang opened the scoring in the first-half with a superb curling effort from the edge of the penalty area, capping a flowing move which had started with goalkeeper Emiliano Martinez.Liverpool’s superior fitness levels began to tell in the second period and Takumi Minamino deservedly drew Jurgen Klopp’s side level in the 73rd minute with his first goal for the club.AdvertisementAdvertisementADVERTISEMENTNeither side was able to force a winner in the closing stages and the game was ultimately decided in a shootout with the Gunners triumphing 5-4. James GoldmanSaturday 29 Aug 2020 7:05 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link7.5kSharescenter_img Ainsley Maitland-Niles impressed again as Arsenal defeat Liverpool on penalties at Wembley (Picture: Getty)After the match, Aubameyang, who stroked home the winning spot kick, was asked to clarify his future, and said: ‘We’re going to see in these days. Today we take the trophy, that’s it. We are improving. ‘There is still work to do but I’m really happy and it’s an exciting time to be an Arsenal player.’More: Arsenal FCArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira movesThomas Partey debut? Ian Wright picks his Arsenal starting XI vs Manchester CityArsene Wenger explains why Mikel Arteta is ‘lucky’ to be managing ArsenalThe future of utility player Ainsley Maitland-Niles, meanwhile, is also the subject of intense speculation with both Wolves and Tottenham expressing an interest in a player Mikel Arteta is desperate to keep. Maitland-Niles was awarded the man-of-the-match award and insisted he sees himself as an Arsenal player until told otherwise. ‘I’m an Arsenal player until I’m told otherwise,’ said the 23-year-old, who also scored in the shootout. ‘He has to be able to convince me every three days,’ said Arteta of the England Under-21 international. ‘At the moment he’s showing he can do it. The best way to show a player what I think of him is whether he plays or not.’MORE: Lucas Torreira’s agent tells Mikel Arteta to make decision on Arsenal star’s futureMORE: Paul Merson urges Arsenal to make ‘big statement’ by completing Gabriel Magalhaes transfer Comment Advertisementlast_img read more


first_img Share Share Tweet Share Sharing is caring!center_img 27 Views   one comment Court gavelJachlena Spliffee Lewis of Stockfarm, who pleaded guilty to the attempted murder of an infant on 23rd November, 2011 was today sentenced to five years imprisonment with a two year suspended sentence, by High Court Judge Bernie Stephenson-Brooks.According to the facts in the case, Lewis delivered baby “A.L” in a pit toilet (outside latrine) on the night of 18th May, 2006 and abandoned her. Baby “A.L” was discovered by a neighbour who went to use the toilet discovered the baby and called the Fire and Ambulance services. Baby “A.L” was rescued and taken to the Princess Margaret Hospital. She was later adopted by a family with whom she still lives.Justice Stephenson-Brooks ordered that the Social Welfare Department conduct interviews with Ms Lewis in order to assist the Court in determining a proper sentence. According to that report, Lewis had been subjected to sexual abuse from a very early age and became a mother when she was sixteen (16) years old. She was also in an extremely abusive common law relationship for four (4) years during which time she bore three (3) children. She is a skilled sea and river diving expert, who is also engaged in craft making for sale on the Roseau Bayfront to provide for her children and herself.The report further indicates that her neighbors describe her as a nice person who has had a hard life and subjected to cruelty, with a tendency to follow bad company. The overall assessment of the Social Welfare Department is that Ms Lewis has a troubled past, incomplete education, early motherhood and domestic abuse.Lewis’ attorney Bernadette Lambert asked the Court to consider that the accused was twenty (20) years old at the time of the incident and already a mother of four (4) children that five years has elapsed since the incident. She also argued that the stigma society places on such incidents is in itself a prison and the Court should consider the fact that her client pleaded guilty and is a first time offender.Ms Lambert also told the Court that her client has continued making her crafts even during the time that she has been remanded at the State’s Prison, making gifts to inmates and prison officer to mark special occasions like birthdays.Arthlyn Nesty who represented the State argued that the accused abused the trust relationship which she had the duty to uphold being the mother of the victim. She asked the Court to also consider the aggravating factors in the case which includes; the breach of trust and care between mother and child, that the victim might be left with a psychological effect as a result of this incident and that the accused concealed the pregnancy.In sentencing the accused Justice Stephenson-Brooks noted the seriousness of the offense which involves the breach of trust and a mother’s role to care for her daughter. She also noted that the accused gave birth to a healthy baby, left her in an outside toilet in the dark and a neighbour rescued her with a torch light.Justice Stephenson-Brooks also highlighted the United Nation’s Convention on the Rights of a Child which Dominica ratified in 1991, in explaining children’s rights to be protected from mental and or physical hurt. She explained that the accused knew that she was pregnant, knew she was about to give birth as she had done so three times before and went to the outside toilet. As a result, the Court must send a clear message to young mothers in society that this behavior is totally unacceptable.Having considered both the aggravating and mitigating circumstances, Justice Stepehson-Brooks sentenced Lewis to five years imprisonment with a two year suspended sentence. The suspended sentence will take effect after she has served three years imprisonment, however since the accused has spent eleven (11) months remanded at the State’s Prison she will only serve two years and one month as of today.The judge also asked Ms Lewis to ponder upon life skills and parenting while she serves her sentence.Dominica Vibes News LocalNews Stockfarm woman sentenced to five years imprisonment for attempted murder of infant by: – December 5, 2011last_img read more