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first_imgMyriads of organisms live in and on our bodies, reminds an article in the Feb. 27 issue of Science,1 and they’re not just freeloaders on a hayride.  We need them, and they need us.  “We are not alone,” claim the three microbiologist authors, but “we get by with a little help from our (little) friends.”  Is this an uneasy truce between enemies, or a loving relationship between friends, promoting health and happiness?  Microbiologists have tended to investigate the nasty germs, but does that focus give a distorted picture?  “Remarkably,” the authors note, “we know far less about the thousands of species that make up our intrinsic microbiota than we know about the few dozen microbes that cause disease.”  We need to start thinking of ourselves as communities, they say:Genomic and evolutionary analyses show us that we are not the single “individuals” that we think we are.  Instead, we and other complex organisms are composed of an interconnected ecosystem of eukaryotic and prokaryotic cells whose interactions can best be understood in the context of community ecology.The authors feel the community is a result of coevolution, but seem somewhat befuddled at the growing realization that many of our beneficial bacteria share mechanisms with the harmful ones.  Friend or foe, they ask:The historical emphasis on pathogenic bacteria and their diseases has led to an assumption that genes encoding virulence factors are specific to those relationships.  However, several of the cellular and molecular mechanisms that underlie interactions between an animal and its beneficial microbiota are remarkably similar to those first found in pathogens.  Svanborg described how molecules that enhance persistence at a site where a given microbe is a member of the normal microbiota can be the very factors that promote disease when these bacteria emigrate to other sites of the body…. Thus, the presence of these genes may indicate the potential for host interactions, which may be pathogenic or benign according to how these genes are regulated or the sensitivity of the tissue in which they are expressed.The Type III secretion systems, for instance, “first described as a mechanism by which animal pathogens hijack their host‘s cell biology, have been implicated in mutualistic associations between nonpathogenic bacteria and their hosts.”  The study of these heretofore misunderstood relationships, they say, forms a “wide-open frontier” with big paradigm shifts ahead:As the depth of host-microbe interactions and the mechanisms underlying them continue to be unraveled, fundamental paradigms of pathogenic microbiology, developmental biology, and immunology will need to be reevaluated.  For this reason, a specific recommendation arising from the workshop is that biology be taught in a new way, incorporating our growing knowledge about the importance of beneficial microbial interactions and their evolutionary, ecological, and biochemical impact on both animals and plants.1Edward Ruby, Brian Henderson, Margaret McFall-Ngai, “Microbiology: We Get By with a Little Help from Our (Little) Friends,” Science.One of the most frequent and hard-to-answer criticisms of creation science has been the presence of pathogens.  Bacteria and viruses, if designed, would seem to be the nefarious products of a malevolent genius rather than of a compassionate Creator.  This was one of the main reasons for Darwin’s slide to agnosticism, from youthful admiration of Paley to middle-aged rejection of Christianity, revelation and purpose in nature.  While most people can appreciate the abundant evidences of design in nature, creationists have been hard pressed to explain disease-causing bacteria and viruses.    But what if they were beneficial living machines running wild, out of bounds and out of control?  The Type III secretion system looks like a weapon, designed to inject poison into a hapless victim.  But could it have originally been like a compassionate doctor’s hypodermic needle, intended for good?  Instead of weapons, were pathogens originally regulatory devices, meant to act as governors on our engines?  Do our metaphors mislead us?  After all, too much of a good thing can be bad.  We need accelerators, but we need brakes, too.    These authors seem open to the possibility that harmful pathogens may be the exception rather than the rule.  They point out that beneficial interactions probably vastly outnumber harmful ones, and at least some of the harmful ones may be beneficial interactions out of kilter.  Their chosen belief is that these interactions “coevolved” on the long Darwinian road from bacteria to man, but this fails to explain the intricate design of even the one-celled organisms.  There is an alternative explanation that should not be arbitrarily dismissed, because it explains good design gone bad: the curse because of sin.    See also 03/14/2003 and 02/21/2002 entries on this subject, and also the next headline, below.(Visited 37 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more


first_imgWhat it Takes to Build a Highly Secure FinTech … Why IoT Apps are Eating Device Interfaces Tags:#mobile#NYT#web audrey watters Role of Mobile App Analytics In-App Engagement The Rise and Rise of Mobile Payment Technology The survey shows wide disparities among immigrant groups about whether or not they would buy a tablet in the near future. Interestingly, although French Americans ranked the highest in terms of tablet ownership, only 34% said they were looking to buy one – putting them last among the different demographics surveyed. Ghanese and Indian Americans topped the list with 62% and 58% respectively indicating that they do plan to buy a tablet soon. Across the board, all demographics surveyed listed the iPad as their tablet of choice.Amazon’s Kindle was the popular second choice as a tablet device, with 9% of those surveyed saying they’re likely to buy one. Ethiopian immigrants expressed the most interest in the Kindle, with 24% saying they’re likely to buy one.The results of the survey, say Andres Bernstrom, CEO of Rebtel, point to a shifting brand identification. “Apple has remained the brand of choice for the immigrant and first generation U.S. market,” he says. “We’re witnessing a massive shift in technology brand affinity over the past decade as Sony has been dethroned, and Apple has grabbed the reigns and held tight starting with the iPod moving forward.”But if these numbers are accurate, they don’t simply mark immigrants’ brand identification and affinity with Apple. A recent Pew Internet and American Life Project study on Americans and their gadgetry found far lower adoptions rates, in general, of tablets. According to its figures, just 4% of Americans own tablets and 5% own e-readers. That’s substantially lower than the 13% in the Rebtel survey. The Rebtel survey doesn’t give any indication of why immigrants would gravitate to tablets at a higher rate. Size? Mobility? Cost? Internet access? Related Posts Mobile VOIP company Rebtel has released results from its latest study on U.S. immigrant consumer mobile usage and behavior. According to its findings, 13% of those who responded said they currently own a tablet device, representing approximately five million Americans.According to the survey, the iPad remains the tablet of choice for immigrants, with two-thirds of current tablet owners indicating they own iPads. According to the survey, French Americans are the highest percentage of tablet owners (17%), followed by Mexican-Americans (15%).last_img read more


first_imgKammuri turning to super typhoon less likely but possible — Pagasa Trending Articles PLAY LIST 00:50Trending Articles04:36Undas 2019: Remembering the dead and reuniting with the living00:51Clarkson on being PH flag-bearer: One of the happiest moments in my career01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games “He brings another championship pedigree, championship DNA,” James said at Cleveland’s media day. “He brings another player to the team who can get guys involved, can make plays and also has a great basketball mind. … I hope we can bring him here. I would love to have him.”Once Wade completes the waiver formality, he’ll be the latest new, high-profile player to join the Cavs, who traded for All-Star point guard Isaiah Thomas, signed former league MVP Derrick Rose and added two strong wing defenders in Jae Crowder and Jeff Green, wing players who may help them defend the Warriors if those teams get back to a fourth straight Finals matchup.Thomas isn’t expected to play until January because of a hip injury, but until he returns the Cavs have plenty of firepower in James, Wade, Rose and All-Star Kevin Love, who could thrive as Cleveland’s No. 2 scoring threat now that Kyrie Irving is in Boston.Wade agreed to a contract buyout earlier this week with the Bulls, who signed him before last season as a free agent.The Cavaliers emerged Tuesday as front-runners over the Heat and Oklahoma City Thunder to land the 35-year-old Wade, who many feel say has plenty of game left.ADVERTISEMENT He’ll now have a shot at another championship — his fourth — while playing alongside James, whom he has been friends with since they broke into the league together in 2003. When James left Cleveland as a free agent in 2010 and signed with Miami, much of his reason for leaving his home state was a chance to play with Wade and Chris Both.Wade played his first 13 seasons in Miami, leaving in the summer of 2016 to sign a two-year deal with the Bulls. But the Bulls are in a rebuilding mode after trading Jimmy Butler this summer, and instead of paying Wade $23.8 million to play for what will likely be a struggling team they agreed this weekend to buy him out and let him find a better situation.In an interview with AP, Wade said that whatever decision he makes would be “a pure basketball decision and I’ll make the one that I feel fits me best at this point in my career and with what I feel I have to offer a team that needs what I have to offer.”Following practice on Tuesday, Cavaliers forward Tristan Thompson said Wade would be a “great” fit in Cleveland.“He’s a guy that’s proven, not just individually, but a team that won three championships,” Thompson said. “He’s pretty familiar with most of the guys on our team. … He’s always been a good locker room guy. We’ve never heard anything bad.“It would be great for our team to have another championship-mentality player.”Wade has averaged 23.3 points, 4.8 rebounds and 5.7 assists in 14 seasons. He averaged 18.3, 4.5 rebounds and 3.8 assists for the Bulls.One of the game’s premiere closers in the postseason, Wade has averaged 22.5 points, 5.3 rebounds and 5.0 assists in 172 playoff games. Wade, a 12-time All-Star, is expected to clear waivers on Wednesday and then join the Cavs, said the person who spoke on condition of anonymity because the deal cannot be completed until Wade goes through the waiver process.In Cleveland, Wade will be reunited with James, his close friend, former Miami teammate and a player he confided in before signing with his hometown Chicago Bulls last year.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutWade and James won two NBA titles together during four seasons with the Heat and will now chase another one with the Cavs, who have been revamped after losing to Golden State in last season’s Finals.On Monday, James said he would “love” to play again with Wade. MOST READ Brace for potentially devastating typhoon approaching PH – NDRRMC Read Next LATEST STORIES E.T. returns to earth, reunites with grown-up Elliott in new ad  Nonong Araneta re-elected as PFF president Frontrow holds fun run to raise funds for young cancer patients  Hotshots reach semis Fire hits houses in Mandaluyong City LOOK: Loisa Andalio, Ronnie Alonte unwind in Amanpulo for 3rd anniversary Dwyane Wade of the Miami Heat talks with LeBron James of the Cleveland Cavaliers during the first half at Quicken Loans Arena on April 2, 2015 in Cleveland, Ohio.Jason Miller/Getty Images/AFPCLEVELAND — Together again: LeBron and D-Wade. Just like old times.Dwyane Wade has decided to sign with the Cleveland Cavaliers and reunite with LeBron James, a person familiar with the situation told the Associated Press on Tuesday night.ADVERTISEMENT BSP sees higher prices in November, but expects stronger peso, low rice costs to put up fight Don’t miss out on the latest news and information. 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first_imgWTF David Beckham has spooky night out ahead of Halloween Goal Last updated 2 years ago 00:12 10/24/17 FacebookTwitterRedditcopy Comments(0) David Beckham Halloween David Beckham / Instagram WTF Premier League Los Angeles’ Halloween Hayride enjoyed a famous guest ahead of the holiday as the ex-England star and his children took in its ghoulish delights Halloween may still be more than a week away, but David Beckham is getting into the holiday spirit early. The former Manchester United, Real Madrid and England midfielder was in Los Angeles with his sons Brooklyn, Romeo and Cruz, and the quartet decided to enjoy a spooky night out. Beckham’s Instagram account was filled by pictures of the famous Halloween hayride, as the family was accosted by creepy clowns, elaborate pumpkins and other scary attractions.  Article continues below Editors’ Picks Lyon treble & England heartbreak: The full story behind Lucy Bronze’s dramatic 2019 Liverpool v Man City is now the league’s biggest rivalry and the bitterness is growing Megan Rapinoe: Born & brilliant in the U.S.A. A Liverpool legend in the making: Behind Virgil van Dijk’s remarkable rise to world’s best player David Beckham Halloween David Beckham Halloween David Beckham HalloweenAll that was missing was a fearsome Sir Alex Ferguson impersonator to really get Beckham trembling!last_img read more


first_img ShareEmailPrint To learn more, read: Posted on November 9, 2010June 20, 2017By: Raji Mohanam, Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to email this to a friend (Opens in new window)Click to print (Opens in new window)I was struck by the insightful comments from panelist Patricia Mechael, Director of Strategic Application of Mobile Technology for Public Health at Columbia University. She spoke at today’s ‘Super Session’ on Lessons Learned Across the Globe. Mechael presented a David Letterman-like top ten list for the mHealth community to help us avoid duplicating work. This notion was repeated in many sessions today. With so many existing and new players in the mHealth field, we do not want to reinvent the wheel and we definitely do not want to reinvent a broken wheel! Mechael made the important point that we all need to capitalize on what others have already done and learned in the mobile health arena. Here is her list or “ten commandments of mHealth” as many are calling it:10. We must unpack the pathways to mobile behavior change and evaluate the impact that mobile technology is really making on health. Let’s answer the question: How are mobile phones changing health-related behavior?9. We need to tease out locally generated content and focus on local context. We need a down up model not top down. Messages need to be indigenously created.8. Let’s move away from a user-satisfaction focus and evaluate the health outcomes. This is the only way to sustain mHealth programs—create targets and benchmarks at the beginning of program creation.7. We must be realistic and become practical about what really works/what doesn’t—integrate mobile technology realistically.6. Let’s invest in participatory design programs—work with who it will impact. We should invest in local developers, designers.5. Let’s take a systems-thinking approach and think about adjacent fields which will be affected in our programs. We need to avoid single-issue thinking—packaging together services will help.4. Collaborate don’t compete—it is not about whose app is best—we all need to win and benefit.3. Recyle, reuse, and repurpose2. mHealth at scale can only come from a leadership linked to local health priorties, that then link to tools.….and the number 1 lesson for the mHealth community:1. It’s not all about technology—its not one system. It’s about a state of health and wellbeing. We’re all impacted. Let’s work together.Share this:last_img read more


first_imgDanielle RochetteAPTN National NewsOfficials with the friendship centre in Val d’Or told the Quebec inquiry that the province is really late in the game when it comes to gathering information it needs to help Indigenous peoples.An inquiry is currently underway in Val d’Or, 525 km northwest of Montreal that is examining the relationship between certain public services and First Nation, Metis and Inuit people.drochette@aptn.calast_img


first_imgTORONTO – Licensed marijuana producer Aphria Inc. (TSX:APH) said it is moving to “purify” its balance sheet by reducing its exposure to medical cannabis in the U.S., where pot remains illegal under federal law, as it undergoes a delisting review by the group which operates the Toronto Stock Exchange.Aphria’s chief executive Vic Neufeld said Monday that it continues to be in discussions with TMX Group, Canada’s biggest exchange operator, which recently warned that companies that operate in states where pot is legal are not in compliance with TSX listing requirements.Neufeld said Aphria plans to submit a brief, including documentation and legal opinions, to the TMX group on its stance before the holiday season as the review wraps by the end of the year. However, he said the Leamington, Ont.-based producer is also moving to reduce its U.S. exposure.“We are trying to endeavour as best as possible, as expeditiously as possible, to divest from Aphria any direct involvement in any medical cannabis that we have in the U.S.,” Neufeld said in an interview.In October, the TMX Group issued a notice cracking down on cross-border marijuana companies with business activities in the U.S. While some states have legalized pot to varying degrees and conditions, under U.S. federal law it remains illegal to cultivate, distribute or possess marijuana.In turn, Canadian marijuana companies had largely focused on markets outside of the U.S. or listed on the smaller Canadian Securities Exchange, which is less risk-averse.However, Aphria in April announced the launch of its U.S. expansion strategy through a strategic investment in an entity that was renamed Liberty Health Sciences Inc. Aphria’s first foray into the U.S. market was in 2016 with an investment in a medical marijuana producer in Arizona called Copperstate Farms, LLC.Neufeld said Monday Aphria is looking to shift its direct stake in Copperstate Farms into Liberty Health Sciences, thereby making it an indirect investment and “purify some of the balance sheet.”Aphria began exploring this option three months ago, and made its request and presentation to Copperstate’s board last month, Neufeld said.However, the company’s request remains subject to a six-month hold agreement that the Arizona-based producer has with its shareholders regarding requests involving any capital transaction, added Neufeld. Aphria has also moved to reduce of its shares in Delaware-based cannabis technology platform MassRoots in recent months.“We’re going to try to purify as much as possible,” said Neufeld. “As long as the Aphria shareholders are not damaged in any which way.”Another option, if that doesn’t satisfy the TMX Group’s requirements, is to hive off Aphria’s U.S. interests into a separate entity and list it on the CSE, but Neufeld said that would be the “last step” as it wants to remain on the TSX.last_img read more


first_imgBETHEL, Alaska — Officials in a western Alaska city have been given the go-ahead to apply for a state public transit grant despite missing the deadline.The Bethel City Council voted Tuesday to apply for the $300,000 grant after residents warned that the city’s bus service would stop in June 2020 if action is not taken, KYUK-AM reported .The grant application was due to the state Department of Transportation on Dec. 17. The grant requires a city match of $80,000.The state grant would fund a new bus, a full-time transit manager, and a part-time and full-time driver.Tundra Women’s Coalition Executive Director Eileen Arnold urged the council to apply, saying the bus system is vital for people who cannot afford a cab or cannot walk long distances in subzero temperatures.“As the executive director of TWC, we are huge users of the bus system, perhaps the largest one,” Arnold said. “It’s really important for the people who are in our shelter.”Bethel resident Susan Charles said she has taken the bus since it started operating in Bethel. Continuing to fund the system makes sense, she said.“We need to get to work, and go home for lunch, and whatever we need to do — go shopping, go to the post office — and the bus system provides that for us here in Bethel,” Charles said.___Information from: KYUK-AM, http://www.kyuk.orgThe Associated Presslast_img read more


first_imgDawson Creek RCMP officers were already in the area on unrelated matters and arrived on scene shortly after the incident. The man was located in the Canadian Tire parking lot and apprehended. DAWSON CREEK, B.C. – The Dawson Creek RCMP responded to a report of a man allegedly shoplifting and threatening staff at the local Walmart with a knife.On Sunday, May 20, a staff member at Walmart reported that while attempting to retrieve what was believed to be stolen merchandise from a man walking out of Walmart, he was threatened as the man brandished a large knife at him saying he was going to kill him. A search of the man located a large kitchen knife, a machete, a small amount of a substance believed to be methamphetamine and some stolen merchandise.The man is currently in police custody, and at this point’s there’s no word on whether charges will be laid.Photos of the knives found on the suspect – D.C. RCMPlast_img read more


first_imgNew Delhi: Surrey’s Will Jacks blazed his way to a 25-ball century, including six sixes in an over, during a pre-season T10 clash with Lancashire in Dubai. In all, he smashed eight boundaries and 11 sixes. After producing the brutal assault on Thursday, the batsman said that he was looking to play shots from the first ball. “From the first ball I just tried to play my shots, after the first few overs my intention was to try and hit every ball for six, and I think after four sixes I thought, ‘I could hit six sixes here’. I had never done it before and it was nice to do that and something I will cherish,” the International Cricket Council quoted Jacks as saying. Had the match been accorded official status, Jasks’ effort would have been bettered Chris Gayle’s world record for the fastest century in competitive cricket, achieved in the 2013 IPL, by five balls. Also Read – Puducherry on top after 8-wkt win over ChandigarhJacks hit Stephen Parry for six sixes in an over on the way to his ton. He also passed the top score of 87 for the 10-over format achieved by Alex Hales last year. Jacks first reached his fifty off just 14 deliveries and then smashed six consecutive sixes to bring up his century. Jacks’ knock powered Surrey to 176 and a 95-run win over Lancashire. The 20-year-old Jacks made his debut for Surrey in first-class, List A and T20 last season, scoring 121 off 100 balls in a Royal London Cup match against Gloucestershire. The match between Surrey and Lancashire was a pre-season fixture for both the teams, who are gearing up for the county season, which begins next month. Also Read – Vijender’s next fight on Nov 22, opponent to be announced laterEven though Jacks’ innings will not be mentioned in the official record books, it is still commendable as it came against a Lancashire side comprising several first-team regulars such as Steven Croft, Parry, Tom Bailey, and Haseeb Hameed. Caribbean batsman Chris Gayle currently holds the record for the fastest individual century which came in just 30 deliveries against Pune Warriors during an IPL match in 2013. Gayle had then played an unbeaten knock of 175 off 66 deliveries, which included 13 fours and 17 sixes, helping his team post a mammoth 263/5 in 20 overs. Former South Africa cricketer AB de Villiers, however, holds the record for the quickest century in international cricket. The left-handed batsman scored a 31-ball century against West Indies in an ODI match in 2015.last_img read more